2025
Biochemical Toxicology
Name: Biochemical Toxicology
Code: QUI12400L
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Biochemistry
Teaching languages: Portuguese
Languages of tutoring support: Portuguese, English
Regime de Frequência: Presencial
Sustainable Development Goals
Learning Goals
To provide:
-basic knowledges about the nature, biotransformation, fate, mechanisms of action and effects of chemicals, its by-products and radiations in biological systems at biochemical level;
-understanding of the integrative concepts, processes and methods to access to knowledge and to solve practical problems on safety and toxicity of chemicals and radiations;
-the development of ability to select and apply knowledge in the formulation of hypotheses, experimental design, and obtaining and processing results, in order to solving qualitative or quantitative family within the scope of this field
-competences to gather, interpret and critique relevant scientific literature, to discuss its implications and communicate scientific ideas and knowledge, in oral and written form, arranged in a logical and consistent manner on matters from the scope of the discipline.
-basic knowledges about the nature, biotransformation, fate, mechanisms of action and effects of chemicals, its by-products and radiations in biological systems at biochemical level;
-understanding of the integrative concepts, processes and methods to access to knowledge and to solve practical problems on safety and toxicity of chemicals and radiations;
-the development of ability to select and apply knowledge in the formulation of hypotheses, experimental design, and obtaining and processing results, in order to solving qualitative or quantitative family within the scope of this field
-competences to gather, interpret and critique relevant scientific literature, to discuss its implications and communicate scientific ideas and knowledge, in oral and written form, arranged in a logical and consistent manner on matters from the scope of the discipline.
Contents
History of Toxicology
Dose-response relationships
Factors afffecting toxic responses
Absoption, distribution, excretion, biotransformation and diposition of toxicants
Factors affecting biotransformation and disposition
Toxic responses to foreign compounds
Biochemical mechanisms of toxicity: Tissue lesions, neurotoxicity, immunotoxicity, teratogenesis, genetic toxicity, chemical carcinogenesis and multi-organ toxicity.
Risks to health and environment associate to toxicants, by-products and radiations
Safety in production, packaging, transportation, storage, dispensing and use of toxicants.
Legislation on toxicants in the EU and in other countries
Dose-response relationships
Factors afffecting toxic responses
Absoption, distribution, excretion, biotransformation and diposition of toxicants
Factors affecting biotransformation and disposition
Toxic responses to foreign compounds
Biochemical mechanisms of toxicity: Tissue lesions, neurotoxicity, immunotoxicity, teratogenesis, genetic toxicity, chemical carcinogenesis and multi-organ toxicity.
Risks to health and environment associate to toxicants, by-products and radiations
Safety in production, packaging, transportation, storage, dispensing and use of toxicants.
Legislation on toxicants in the EU and in other countries
Teaching Methods
The discipline includes theoretical classes, tutorials and practical classes, in accordance with the internal UÉvora regulation.
The theoretical classes are plenary sessions using the scientific method, and includes search of information, interpretation of experimental work results and the development of a critical attitude and scientific rigour.
Practical classes includes the fundamentals of the methods, the experimental procedures and resolution of quantitative problems.
In laboratorial classes, students are organized by groups, and must actively participate in the preparation, execution and discussion of the results and must prepare a report concerning the laboratorial work.
The laboratory work evaluation includes: observation by scales of individual participation of students in groups; response to issues raised in the classroom; presentation of relevant scientific articles and evaluation reports.
Finally, they are submited to 1 midterm and 1 final written tests or 1 final written exam.
The theoretical classes are plenary sessions using the scientific method, and includes search of information, interpretation of experimental work results and the development of a critical attitude and scientific rigour.
Practical classes includes the fundamentals of the methods, the experimental procedures and resolution of quantitative problems.
In laboratorial classes, students are organized by groups, and must actively participate in the preparation, execution and discussion of the results and must prepare a report concerning the laboratorial work.
The laboratory work evaluation includes: observation by scales of individual participation of students in groups; response to issues raised in the classroom; presentation of relevant scientific articles and evaluation reports.
Finally, they are submited to 1 midterm and 1 final written tests or 1 final written exam.
Teaching Staff
- Ana Cristina Bugalho Oliveira Rodrigues Costa [responsible]
Certificações
