Pharmaceutical Chemistry I

Code: CMS13732I

6 ECTS

Duration: 15 weeks/156 hours

Scientific Area: Ciências Farmacêuticas

Teaching languages: Portuguese

Languages of tutoring support: Portuguese, English

Regime de Frequência: Presencial

Presentation

UC Química Farmacêutica I presents several aspects of chemistry associated with the search, obtainment, analysis and development of drugs, valuing their interaction with the respective therapeutic targets and with their therapeutic application in different pathologies

Sustainable Development Goals

Saúde de qualidade - Assegurar uma vida saudável e promover o bem-estar para todos, em todas as idades.

Educação de qualidade - Assegurar a educação inclusiva, e equitativa e de qualidade, e promover oportunidades de aprendizagem ao longo da vida para todos.

Learning Goals

The general objective of this UC is to provide the student with a set of scientific knowledge and develop their skills of reflection and criticism in the field of Pharmaceutical Chemistry. The student must know and understand the fundamental concepts and principles related to the molecular mechanisms of action and the interrelationship between structure, chemical properties, pharmacological activity and therapeutic utility, and the pharmacokinetic parameters used in the study and evaluation of drugs. The student must also know and understand the main methods and strategies of design, discovery and development of new drugs, and apply the chemical and molecular foundations of action of drugs in the optimization of prototypes and in the rational design of new therapeutic agents.
The student must be able to apply the knowledge obtained to different groups of drugs.
The student must also be able to perform the preparation, isolation and analysis of some drugs.

1. Introduction to Pharmaceutical Chemistry: object of study and historical perspective. Nomenclature and classification of drugs.
2. General cycle of drugs in the body. Chemical and structural properties of drugs and their pharmacokinetics: Absorption, Distribution, Metabolism and Excretion of drugs. Prodrugs.
3. Drugs and their action: molecular mechanisms of drug action in the main groups of biomolecules. Drugs acting on enzymes, protein receptors and nucleic acids.
4. Qualitative and quantitative structure-activity relationships: SAR, QSAR, 3DQSAR.
5. Main sources of drugs. Methods of searching, finding and isolating new drugs.
6. Development and production of new drugs.
7. Chemical structures, mechanisms of action, structure-activity relationship, pharmacokinetics and applications of i) antibacterial, antifungal, antiviral and other anti-infectious agents; ii) antineoplastic agents.
8. Preparation, isolation and analysis of drugs.

Teaching Methods

The process of teaching/learning is based on the individual work of students, supported by recommended literature and didactic materials provided by the teacher. The theoretic lectures are lessons of exposition of the subjects, resolution of some exercises, answering questions and discussion of related topics. Laboratory classes work articulated and complementary with other lectures, using the planning and execution of laboratory work which implements practical examples.
The assessment will be based on measuring the acquisition of knowledge, understanding and measurement of skills developed in the different components of the course. The evaluation of the theoretical part (80%) take place by a written exam (with an option for two tests). The practical evaluation (10%) is done through the reports of practical work with the treatment and interpretation of the experimental results. This assessment is complemented by the presentation of a small work about a paper or a drug (10%).