2023
Pharmaceutical Chemistry
Name: Pharmaceutical Chemistry
Code: QUI13550M
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Chemistry
Teaching languages: Portuguese
Languages of tutoring support: Portuguese, English
Regime de Frequência: Presencial
Sustainable Development Goals
Learning Goals
The general aim of this course is to provide students with a set of knowledge in the field of Pharmaceutical Chemistry. Students should know and understand the fundamental concepts and principles of Pharmaceutical Chemistry, the molecular mechanisms of action and the interrelationship between structure, chemical properties, pharmacological activity and therapeutic utility, pharmacokinetic parameters used in the study and evaluation of drugs, as well as how to understand the main methods and strategies of design, discovery and development of new drugs and the complexity of all process. Students should also be able to perform the preparation, isolation and analysis of some drugs. Students should also be able to apply the knowledge gained to the study of new molecules and development of new drugs and to develop critical sense and problem solving skills in Pharmaceutical Chemistry.
Contents
- Introduction to Pharmaceutical Chemistry: object of study and historical perspective. Nomenclature and classification of drugs.
- General cycle of drugs in the body. Chemical and structural properties of compounds and their pharmacokinetics: Absorption, Distribution, Metabolism and Excretion of drugs; prodrugs.
- Drugs and their action: molecular mechanisms of drug action in the main groups of biomolecules. Receivers.
- Qualitative and quantitative structure-activity relationships: SAR, QSAR, 3DQSAR.
- Main sources of drugs. Methods of searching, finding and isolating new drugs. The contribution of Natural Product Chemistry, Combinatorial Chemistry, Computational Chemistry and Chemical Synthesis and Asymmetric Synthesis.
- Development and production of new drugs.
- Study of some drugs: chemical structures, mechanisms of action, structure-activity relationship, pharmacodynamics, pharmacokinetics and applications.
- Preparation, isolation and analysis of drugs.
- General cycle of drugs in the body. Chemical and structural properties of compounds and their pharmacokinetics: Absorption, Distribution, Metabolism and Excretion of drugs; prodrugs.
- Drugs and their action: molecular mechanisms of drug action in the main groups of biomolecules. Receivers.
- Qualitative and quantitative structure-activity relationships: SAR, QSAR, 3DQSAR.
- Main sources of drugs. Methods of searching, finding and isolating new drugs. The contribution of Natural Product Chemistry, Combinatorial Chemistry, Computational Chemistry and Chemical Synthesis and Asymmetric Synthesis.
- Development and production of new drugs.
- Study of some drugs: chemical structures, mechanisms of action, structure-activity relationship, pharmacodynamics, pharmacokinetics and applications.
- Preparation, isolation and analysis of drugs.
Teaching Methods
The process of teaching/learning is based on the individual work of students, supported by recommended literature and in research conducted individually. The theoretic lectures are lessons of exposition of the subjects, resolution of some exercises, answering questions and discussion of related topics. Laboratory classes work articulated and complementary with other lectures, using the planning and execution of laboratory work which implements practical examples.
The assessment will be based on measuring the acquisition of knowledge, understanding and measurement of skills developed in the different components of the course. The evaluation of the theoretical part (60%) take place by a written exam (with an option for two tests). The practical evaluation (10%) is done through the reports of practical work with the treatment and interpretation of the experimental results. This assessment is complemented by the presentation of a small monograph about a drug (30%).
The assessment will be based on measuring the acquisition of knowledge, understanding and measurement of skills developed in the different components of the course. The evaluation of the theoretical part (60%) take place by a written exam (with an option for two tests). The practical evaluation (10%) is done through the reports of practical work with the treatment and interpretation of the experimental results. This assessment is complemented by the presentation of a small monograph about a drug (30%).
Teaching Staff
- António Paulo da Silva Teixeira [responsible]
