2023
Physiological Biochemistry II
Name: Physiological Biochemistry II
Code: CMS14311L
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Biochemistry, Biological Sciences
Teaching languages: Portuguese
Languages of tutoring support: Portuguese, English
Regime de Frequência: Presencial
Presentation
Physiological Biochemistry II offers an integrated view of metabolism and its regulation in the human body, in different metabolic states. It also addresses the underlying components of some metabolic pathologies.
It must be preceded by Physiological Biochemistry I.
It must be preceded by Physiological Biochemistry I.
Sustainable Development Goals
Learning Goals
The general objective of this curricular unit is to provide students with knowledge in the field of Integrative Human Biochemistry. Specifically, it is intended that students acquire knowledge allowing them to understand the organization of metabolism, the interplay and regulation of metabolism at the molecular, cellular and body level as well as the metabolic homeostasis and the role of changes at the molecular level in metabolic pathologies.
Students should: identify the different metabolic pathways, the interplay between pathways; develop an integrated overview of the metabolism and to know and to understand its regulation at the cellular and body level; identify and understand the contribution of molecular changes to metabolic pathologies; analyse results and apply the acquired knowledge to new situations in this or other scientific area; the development of an analytical and investigative attitude with scientific rigour.
Students should: identify the different metabolic pathways, the interplay between pathways; develop an integrated overview of the metabolism and to know and to understand its regulation at the cellular and body level; identify and understand the contribution of molecular changes to metabolic pathologies; analyse results and apply the acquired knowledge to new situations in this or other scientific area; the development of an analytical and investigative attitude with scientific rigour.
Contents
Introduction to metabolism.
Energy Conservation in Metabolism: The Mechanisms of ATP Synthesis. Fermentation and Oxidative Phosphorylation.
Catabolism of the Major Biomolecules: Tricarboxylic Acid Cycle. Catabolism of Carbohydrates, Lipids and Amino Acids. Regulation of catabolism.
Regulation and Integration of Metabolism in the Absorptive State: Glucose Sensing by Cells. Biosynthesis of Glycogen and Lipids. Role of Insulin.
Regulation and Integration of Metabolism During Hypoglycemia: Overview of Metabolism During Fasting. Glycogen Degradation in the Liver. Gluconeogenesis: reactions and precursors. Role of Glucagon and Glucocorticoids.
Regulation and Integration of Metabolism During Physical Activity: Metabolic Pathways for ATP Synthesis in the Skeletal Muscle. Hormonal Regulation: Role of Adrenaline.
Control of Body Weight and the Metabolic Syndrome: Humoral Control of Food Ingestion. Leptin, Intestinal Peptides and Ghrelin. Adaptive Thermogenesis. Role of Thyroid Hormones. Obesity.
Energy Conservation in Metabolism: The Mechanisms of ATP Synthesis. Fermentation and Oxidative Phosphorylation.
Catabolism of the Major Biomolecules: Tricarboxylic Acid Cycle. Catabolism of Carbohydrates, Lipids and Amino Acids. Regulation of catabolism.
Regulation and Integration of Metabolism in the Absorptive State: Glucose Sensing by Cells. Biosynthesis of Glycogen and Lipids. Role of Insulin.
Regulation and Integration of Metabolism During Hypoglycemia: Overview of Metabolism During Fasting. Glycogen Degradation in the Liver. Gluconeogenesis: reactions and precursors. Role of Glucagon and Glucocorticoids.
Regulation and Integration of Metabolism During Physical Activity: Metabolic Pathways for ATP Synthesis in the Skeletal Muscle. Hormonal Regulation: Role of Adrenaline.
Control of Body Weight and the Metabolic Syndrome: Humoral Control of Food Ingestion. Leptin, Intestinal Peptides and Ghrelin. Adaptive Thermogenesis. Role of Thyroid Hormones. Obesity.
Teaching Methods
The teaching/learning process is based on the individual work of the students, supported by theoretical classes (35h), theoretical practices (13h) and laboratory practices (15h) and the recommended bibliography.
The evaluation system is organized to consider the work carried out by the student in the different components. The practical component (PS) is continuously evaluated considering the attendance, the performance in the laboratory and the analysis, interpretation and discussion of results (oral and/or essay). The theoretical and theoretical-practical component (TS) can be evaluated in two modalities: continuous (written test) or by final exam.
The final score (FS) will be calculated on base of practical component score (PS), and of the theoretical component score (FS): FS=0.25*PS+0.75*TS.
The evaluation system is organized to consider the work carried out by the student in the different components. The practical component (PS) is continuously evaluated considering the attendance, the performance in the laboratory and the analysis, interpretation and discussion of results (oral and/or essay). The theoretical and theoretical-practical component (TS) can be evaluated in two modalities: continuous (written test) or by final exam.
The final score (FS) will be calculated on base of practical component score (PS), and of the theoretical component score (FS): FS=0.25*PS+0.75*TS.
Teaching Staff
- Célia Maria Miguel Antunes [responsible]
- Pedro Miguel Amores da Silva
