2024
Biochemical Pharmacology
Name: Biochemical Pharmacology
Code: CMS13554M
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Biochemistry
Teaching languages: Portuguese
Languages of tutoring support: Portuguese
Sustainable Development Goals
Learning Goals
Understanding the phenomena that occur from absorption to the metabolism of drugs, distribution and metabolism.
Knowing how the interaction of drugs with sites where they exert their modes of action
Knowing the general principles of action of drugs and the effects caused by them
Distinguish Pharmacokinetics of Pharmacodynamics.
Knowing the different families of drugs and their modes of action and effects.
Knowing how the interaction of drugs with sites where they exert their modes of action
Knowing the general principles of action of drugs and the effects caused by them
Distinguish Pharmacokinetics of Pharmacodynamics.
Knowing the different families of drugs and their modes of action and effects.
Contents
Introduction
Historical Review
Nature as a source of medicines
Part I
Pharmacokinetics
Pharmacodynamics
Pharmacological action and effect
Drug-receptor, ligand-receptor and pharmacodynamic interactions
Increased or decreased effects due to drug action mechanisms
Transduction signals
Effect of drugs
Quantification of the effect of drugs
Quantification of reversible and irreversible effects
Quantitative pharmacodynamic models
Maximum effect and potency of a drug
Effect of agonist and antagonist drugs
Individual variations of drug response
Part II
Drug classes
Drugs that act on synapses and neuroeffective junctions and acting on the central nervous system
Autacoids
Drugs that affect renal and cardiovascular functions and gastrointestinal function
Anti-microbial and anti-parasitic chemotherapy
Chemotherapy of neoplastic diseases
Immunomodulators
Drugs acting on blood and hematopoietic organs
Hormones and their antagonists.
Historical Review
Nature as a source of medicines
Part I
Pharmacokinetics
Pharmacodynamics
Pharmacological action and effect
Drug-receptor, ligand-receptor and pharmacodynamic interactions
Increased or decreased effects due to drug action mechanisms
Transduction signals
Effect of drugs
Quantification of the effect of drugs
Quantification of reversible and irreversible effects
Quantitative pharmacodynamic models
Maximum effect and potency of a drug
Effect of agonist and antagonist drugs
Individual variations of drug response
Part II
Drug classes
Drugs that act on synapses and neuroeffective junctions and acting on the central nervous system
Autacoids
Drugs that affect renal and cardiovascular functions and gastrointestinal function
Anti-microbial and anti-parasitic chemotherapy
Chemotherapy of neoplastic diseases
Immunomodulators
Drugs acting on blood and hematopoietic organs
Hormones and their antagonists.
Teaching Methods
The unit is organized in theoretical and practical group sessions and tutorials.
The collective sessions of theoretical nature are plenary and based on the scientific method, valuing the research of information, the interpretation of results and the development of a critical attitude and scientific rigor.
In practical sessions, the fundamentals of the methods, the experimental procedures and the quantitative problems are solved. In these sessions, students organized by groups should: actively participate in the preparation and execution of the work, in the discussion of the results, and individually prepare the work reports.
The assessment is individual. The laboratory (40%) includes: scale observation of individual student participation in groups; answer questions in class; presentation and discussion by students of relevant scientific articles and evaluation of reports. The theoretical assessment (60%) includes the option for completion of 2 written tests or a final exam.
The collective sessions of theoretical nature are plenary and based on the scientific method, valuing the research of information, the interpretation of results and the development of a critical attitude and scientific rigor.
In practical sessions, the fundamentals of the methods, the experimental procedures and the quantitative problems are solved. In these sessions, students organized by groups should: actively participate in the preparation and execution of the work, in the discussion of the results, and individually prepare the work reports.
The assessment is individual. The laboratory (40%) includes: scale observation of individual student participation in groups; answer questions in class; presentation and discussion by students of relevant scientific articles and evaluation of reports. The theoretical assessment (60%) includes the option for completion of 2 written tests or a final exam.
Teaching Staff (2023/2024 )
- Ana Margarida Molhinho Advinha
- António Manuel Neto Vaz [responsible]
