2023
Organic Synthesis
Name: Organic Synthesis
Code: QUI13533L
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Chemistry
Teaching languages: Portuguese
Languages of tutoring support: Portuguese
Sustainable Development Goals
Learning Goals
Synthesis of polifunctional compounds. Protective groups. Retrosynthetic analysis. Reactivity of organometallic compounds. Organometallic compounds in Organic Synthesis.
Laboratory experiments for:
a) synthesis of organic compounds using protecting group;
b) synthesis of organic compounds using organometallic catalysts;
c) application of fundamental techniques of isolation, characterization and identification of organic compounds
Laboratory experiments for:
a) synthesis of organic compounds using protecting group;
b) synthesis of organic compounds using organometallic catalysts;
c) application of fundamental techniques of isolation, characterization and identification of organic compounds
Contents
Synthesis and reactivity of 1,3-dicarbonyl compounds. Synthesis of -hydroxyketones.
Protective groups: a) acetal; b) protecting groups for alcohols; c) protecting groups for amines.
Retrosynthetic analysis. Disconnections. Idealized reagents: synthons. Equivalent reagents.Two-group disconnections. Multiple step synthesis. Functional group interconversion. Amine synthesis using functional group interconversion.
Reactivity of organometallic compounds: a) ligand substitution; b) oxidative addition and reductive elimination; c) insertion and elimination; d) electrophilic and nucleophilic addition and abstraction. Organometallic compounds in Organic Synthesis.
Protective groups: a) acetal; b) protecting groups for alcohols; c) protecting groups for amines.
Retrosynthetic analysis. Disconnections. Idealized reagents: synthons. Equivalent reagents.Two-group disconnections. Multiple step synthesis. Functional group interconversion. Amine synthesis using functional group interconversion.
Reactivity of organometallic compounds: a) ligand substitution; b) oxidative addition and reductive elimination; c) insertion and elimination; d) electrophilic and nucleophilic addition and abstraction. Organometallic compounds in Organic Synthesis.
Teaching Methods
The teaching/learning process is based on the students' individual work, supported by the teacher's recommended bibliography and notes obtained by the students during the classes and on individual research. The lectures are classes of exposition of the subject during which there is the resolution of some exercises, clarification of doubts and discussion of topics related to the subject taught.
The laboratory practical classes work in conjunction with and complement the theoretical classes, using the planning and execution of laboratory work that gives practical examples of theoretical contents.
The students evaluation in this curricular unit will have two components, a theoretical and a laboratory practice. For the evaluation of the theoretical component students have two optional modalities, the frequency (2 tests) or the final exam.
The final evaluation is given by the contribution of the theoretical components (70%) and laboratory practice (30%).
The laboratory practical classes work in conjunction with and complement the theoretical classes, using the planning and execution of laboratory work that gives practical examples of theoretical contents.
The students evaluation in this curricular unit will have two components, a theoretical and a laboratory practice. For the evaluation of the theoretical component students have two optional modalities, the frequency (2 tests) or the final exam.
The final evaluation is given by the contribution of the theoretical components (70%) and laboratory practice (30%).
Teaching Staff (2022/2023 )
- António Manuel Deométrio Rodrigues Lourenço Pereira [responsible]
