2025
General Pharmacology
Name: General Pharmacology
Code: CMS13754I
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Ciências Farmacêuticas
Teaching languages: Portuguese
Languages of tutoring support: Portuguese
Regime de Frequência: Presencial
Presentation
This unit aims to provide the students with the knowledge on Pharmacology in order to understand the concepts of biopharmacy and bioavailability and bioequivalence; identify the different routes of drug administration; and understand pharmacokinetic concepts that allow establish dosing regimens.
Sustainable Development Goals
Learning Goals
Understand the concept and purpose of biopharmacy.
Understand the concepts of bioavailability and bioequivalence.
Know the set of processes that characterize the temporal evolution of the drug after administration in the body according to a specific route of administration (LADME);
Identify the importance of different routes of drug administration;
Classify and understand pharmacokinetic models;
Recognize problems of therapeutic inequality of medicines caused by biological or technological aspects;
Understand pharmacokinetic concepts that allow you to establish and change the most common dosing regimens.
Understand the concepts of bioavailability and bioequivalence.
Know the set of processes that characterize the temporal evolution of the drug after administration in the body according to a specific route of administration (LADME);
Identify the importance of different routes of drug administration;
Classify and understand pharmacokinetic models;
Recognize problems of therapeutic inequality of medicines caused by biological or technological aspects;
Understand pharmacokinetic concepts that allow you to establish and change the most common dosing regimens.
Contents
Introduction to biopharmacy.
Concept and applications: research and development of medicines and their therapeutic use.
Bioavailability studies and factors that can affect bioequivalence. Parameters for assessing bioavailability. Bioequivalence testing methodologies.
Study of release, absorption, distribution, metabolism and excretion processes (LADME).
Classification: parenteral and enteral routes. Kinetic processes of LADME. Distribution and volume of distribution. Binding to plasma proteins and tissues. Metabolization. Excretion routes
Routes of medication administration: enteral, parenteral and topical. Anatomophysiological aspects and factors that affect the action of the drug.
Pharmacokinetic models and parameters. Compartmental and physiological models.
Urinary excretion curves. Speed and cumulative curves.
Dose regimen design. Selection of the dosing interval, maintenance dose and shock. Controlled release formulations.
Drug administration in irregular multiple dose regimens.
Concept and applications: research and development of medicines and their therapeutic use.
Bioavailability studies and factors that can affect bioequivalence. Parameters for assessing bioavailability. Bioequivalence testing methodologies.
Study of release, absorption, distribution, metabolism and excretion processes (LADME).
Classification: parenteral and enteral routes. Kinetic processes of LADME. Distribution and volume of distribution. Binding to plasma proteins and tissues. Metabolization. Excretion routes
Routes of medication administration: enteral, parenteral and topical. Anatomophysiological aspects and factors that affect the action of the drug.
Pharmacokinetic models and parameters. Compartmental and physiological models.
Urinary excretion curves. Speed and cumulative curves.
Dose regimen design. Selection of the dosing interval, maintenance dose and shock. Controlled release formulations.
Drug administration in irregular multiple dose regimens.
Teaching Methods
Collective contact sessions for the transmission of fundamental knowledge where active methodologies that appeal to student / student interaction will be used, such as theoretical and practical activities, debates, group / peer research work, problem solving / exploration of CTS & A situations, which allows cooperative learning, a very effective method of solving problems and promoting learning.
The evaluation will be carried out in two components: one, in a group, by the presentation and discussion of results obtained from the realization of alpha numerical problems related to dosing (30%) ; another, for the written evaluation (70%), which, by option, can be for the accomplishment of 2 written tests in the middle and at the end of the semester or just 1 final written exam.
The evaluation will be carried out in two components: one, in a group, by the presentation and discussion of results obtained from the realization of alpha numerical problems related to dosing (30%) ; another, for the written evaluation (70%), which, by option, can be for the accomplishment of 2 written tests in the middle and at the end of the semester or just 1 final written exam.
Teaching Staff
Certificações
