Pharmaceutical Chemistry II

Code: CMS13733I

6 ECTS

Duration: 15 weeks/156 hours

Scientific Area: Ciências Farmacêuticas

Teaching languages: Portuguese

Languages of tutoring support: Portuguese

Regime de Frequência: Presencial

Presentation

UC Química Farmacêutica II presents several aspects of chemistry associated with the therapeutic use of drugs, valuing their obtainment and interaction with the respective therapeutic targets and their therapeutic application in different pathologies.

Sustainable Development Goals

Saúde de qualidade - Assegurar uma vida saudável e promover o bem-estar para todos, em todas as idades.

Educação de qualidade - Assegurar a educação inclusiva, e equitativa e de qualidade, e promover oportunidades de aprendizagem ao longo da vida para todos.

Learning Goals

The objectives of this UC continue those developed in Pharmaceutical Chemistry I, completing the acquisition of knowledge about groups of drug, understanding the diversity of their structures, their chemical and pharmacokinetic properties, the mechanisms of action on their therapeutic targets, relating their chemical characteristics to their pharmacological activity. Among the studied groups of drugs are also drugs of an inorganic nature.
Students must complete the acquisition of this knowledge with the ability to apply it to the development and optimization strategies of drugs.
Students must also be able to solve problems related to theoretical concepts.
Students should also improve their skills in the preparation and analysis of drugs by carrying out experimental activities.

Chemical structures, mechanisms of action, structure-activity relationship, pharmacokinetics and applications of the following groups of drugs:
- Drugs that act on the Central Nervous System, as stimulants or as depressants; therapies in Parkinson's and Alzheimer's diseases;
- Centrally acting analgesics,
- Analgesics, antipyretics and anti-inflammatory drugs;
- General and local anesthetics;
- Antihistamine agents;
- Steroidal and non-steroidal agents used in hormonal disorders;
- Agents that act on the cardiovascular system,
- Agents acting on the renal system,
- Agents of an inorganic nature: drugs with applications in osteoporosis and cancer treatment; drugs used in diagnostic imaging.
Laboratorial component: Preparation, isolation and analysis of drugs.

Teaching Methods

The process of teaching/learning is based on the individual work of students, supported by recommended literature and didactics materials provided by the teacher. The theoretic lectures are lessons of exposition of the subjects, resolution of some exercises, answering questions and discussion of related topics. Laboratory classes work articulated and complementary with other lectures, using the planning and execution of laboratory work which implements practical examples.
The assessment will be based on measuring the acquisition of knowledge, understanding and measurement of skills developed in the different components of the course. The evaluation of the theoretical part (70%) take place by a written exam (with an option for two tests). The practical evaluation (10%) is done through the reports of practical work with the treatment and interpretation of the experimental results. This assessment is complemented by the presentation of a small monograph about a drug (20%).