2025
Disease: from Mechanisms to Clinic I
Name: Disease: from Mechanisms to Clinic I
Code: CMS15062M
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Biomedical Sciences, Health Sciences
Teaching languages: Portuguese
Languages of tutoring support: Portuguese, English
Regime de Frequência: Presencial
Sustainable Development Goals
Learning Goals
This course is structured so that students can acquire knowledge and skills on the structure and function of the 1) Gastrointestinal System, 2) Urinary System, 3) Endocrine System and 4) Reproductive System, covering the molecular mechanisms of diseases affecting each system, risk factors, clinical manifestations, means of diagnosis and their treatment, in particular precision treatment aimed at therapeutic targets. The aim is also to enable students to discuss clinical cases and stimulate the use of creative and critical skills (critical analysis of the literature). It is also intended for the student to develop oral and written communication skills and group work capabilities.
At the end of the course, students should be able to understand and describe the molecular mechanisms underlying the pathologies of the systems studied, identify means of diagnosis and know the main therapeutic strategies for each of them.
At the end of the course, students should be able to understand and describe the molecular mechanisms underlying the pathologies of the systems studied, identify means of diagnosis and know the main therapeutic strategies for each of them.
Contents
1- Gastrointestinal Tract Diseases.
Anatomy and physiology. Benign and malignant pathology of the esophagus, stomach and duodenum, colon and rectum, liver, gallbladder and bile ducts and pancreas.
2- Urinary tract disease
Anatomy of the urinary system and renal histology; Physiology; Renal functions; Semiology; Hydro-electrolytic and acid-base balance; Chronic renal disease; Glomerulonephritis; Interstitial nephritis; Secondary nephropathies: Diabetic nephropathy; Autoimmune disease; Hepato-renal syndrome; Hypertension and the kidney; Cancer of the urothelial system and the kidney.
3- Endocrine System Diseases
Hypothalamus-Hypophysis: anatomy and physiology; hypothalamic-pituitary insufficiencies; thyroid and adrenal pathology; diabetes mellitus; phosphorus and calcium metabolism; multiple endocrine neoplasms and autoimmune polyglandular syndromes; lipid metabolism and dyslipidemia.
4- Reproductive system diseases.
Ovarian anatomy and physiology: from puberty to menopause. Benign and m
Anatomy and physiology. Benign and malignant pathology of the esophagus, stomach and duodenum, colon and rectum, liver, gallbladder and bile ducts and pancreas.
2- Urinary tract disease
Anatomy of the urinary system and renal histology; Physiology; Renal functions; Semiology; Hydro-electrolytic and acid-base balance; Chronic renal disease; Glomerulonephritis; Interstitial nephritis; Secondary nephropathies: Diabetic nephropathy; Autoimmune disease; Hepato-renal syndrome; Hypertension and the kidney; Cancer of the urothelial system and the kidney.
3- Endocrine System Diseases
Hypothalamus-Hypophysis: anatomy and physiology; hypothalamic-pituitary insufficiencies; thyroid and adrenal pathology; diabetes mellitus; phosphorus and calcium metabolism; multiple endocrine neoplasms and autoimmune polyglandular syndromes; lipid metabolism and dyslipidemia.
4- Reproductive system diseases.
Ovarian anatomy and physiology: from puberty to menopause. Benign and m
Teaching Methods
Theoretical classes will be expository, using audiovisual materials made available to students on the Moodle platform. They will be used above all to present the fundamental concepts that will then be worked on and deepened in the TP classes. These will take place in small groups and will use the flipped classroom (FC) and Problem-Based Learning (PBL) as the preferred methodologies. In the FC, in-depth documents on the topics (previously presented in the Theoretical class) will be made available in advance on Moodle, for individual preparation, and the will be used to carry out group activities that allow application of fundamental concepts. TP-PBL classes will allow concepts to be applied to real-life learning scenarios, particularly the discussion of clinical cases. The PL classes are intended for a TBL session that contributes to the construction of knowledge in a collaborative, proactive way, promoting critical thinking and teamwork.
Assessment
The theoretical evaluation is worth 70% and can be done continuously in 2 assessment components, each with 50% weight in the final theoretical grade. Alternatively, a final exam (theoretical and written) can be taken, covering all the contents of the course with a single test.
The theoretical-practical assessment is worth 20% and is carried out through active participation in (10%) and presentation of written work, carried out in groups (10%). The student receives feedback on the initial versions of the work and can improve, with the final product being graded.
The LP assessment is worth 10%.
The final grade (NF) (whether continuous assessment or final assessment) results from the weighting of the T, TP and PL assessment. NF= T*0.7+TP*0.2+PL*0.1.
The theoretical-practical assessment is worth 20% and is carried out through active participation in (10%) and presentation of written work, carried out in groups (10%). The student receives feedback on the initial versions of the work and can improve, with the final product being graded.
The LP assessment is worth 10%.
The final grade (NF) (whether continuous assessment or final assessment) results from the weighting of the T, TP and PL assessment. NF= T*0.7+TP*0.2+PL*0.1.
Certificações
