How genetically different is a domestic pig from a wild boar? Detecting molecular signatures of differential selection in candidate genes involved in domestication process and molecular adaptation in domestic and wild pig.
- Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares(líder)
- Universidade de Évora(parceiro)
Summary
LOCAL BREED ARE RESERVOIRS OF GENETIC DIVERSITY AND HAVE A LONG HISTORY OF ADAPTATION TO EXTREME CONDITIONS (e.g., parasites, climates, food) it is FUNDAMENTAL TO SCREEN THE GENE pool of those breeds and wild populations to better understand the (1) molecular adaptation, (2) differential selection, (3) potential ongoing gene-flow between wild and domestics, its benefits an caveats, and (4) re-assess the evolutionary history and the domestication process of pig. The approach proposed in this study, is based on COMPARATIVE ANALYSIS OF THE SEQUENCES FROM 100 CANDIDATE GENES, IN A TOTAL OF TWELVE DOMESTIC POPULATIONS UNDER DIFFERENTIAL SELECTION PRESSURE. This approach will permit the identification of SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) AND HAPLOTYPES TO BE TESTED FOR SELECTION SIGNATURES AT THE MOLECULAR LEVEL USING CUTTING-EDGE STATISTICAL TESTS.
Goals, activities and expected/achieved results
Goals
1. Identify molecular variation and conduct a phylogenetic and frequency-based test of the (nearly) neutral theory. 2. Quantify the role of mutation, recombination, selection and genetic drift in the evolution and adaptation of domestic species to new environments. 3. Understand the process of domestication of the pig and its impact in the current in genome of the domesticated species.
Activities
Publish FOUR PAPERS (target SCI journal). It is expected that these data and results will also be defused in handbooks.
| Attribute | Type | Value |
|---|---|---|
| id | integer | 1240 |
