2024
Introduction to Pharmaceutical Chemistry
Name: Introduction to Pharmaceutical Chemistry
Code: QUI13517L
3 ECTS
Duration: 15 weeks/78 hours
Scientific Area:
Chemistry
Teaching languages: Portuguese
Languages of tutoring support: Portuguese
Sustainable Development Goals
Learning Goals
The general objective of this course is to provide the student with a basic knowledge in the area of Pharmaceutical Chemistry. The student must identify the object of study of Pharmaceutical Chemistry, know and understand the fundamental concepts and principles and recognize its multidisciplinarity. The student should know and understand the main modes of interaction between the drug and its target, as well as know the importance and influence of the chemical and structural properties of the compounds to reach the therapeutic target. Students should also learn about the major sources of drugs, the complexity of the research and development process for new drugs, and the role of regulatory authorities in the drug approval process. The student should also develop a critical sense regarding research and reading information related to drugs.
Contents
1. Introduction to Pharmaceutical Chemistry; object of study. Therapeutic and drug evolution throughout history.
2. Nomenclature of drugs.
3. Main sources of obtaining drugs. Inorganic and organometallic drugs.
4. Molecular targets and mode of action of drugs. Drug interaction with molecular targets; pharmacophorus; receptor. Agonists and antagonist. Prodrugs.
5. Importance of stereoisomerism, ionization, solubility and lipophilia; partition coefficient on drug activity. Stability of drugs.
6. Main steps in obtaining a new drug: discovery, design and development of a drug.
7. The role of regulatory authorities (INFARMED, EMA and FDA) in drug approval.
2. Nomenclature of drugs.
3. Main sources of obtaining drugs. Inorganic and organometallic drugs.
4. Molecular targets and mode of action of drugs. Drug interaction with molecular targets; pharmacophorus; receptor. Agonists and antagonist. Prodrugs.
5. Importance of stereoisomerism, ionization, solubility and lipophilia; partition coefficient on drug activity. Stability of drugs.
6. Main steps in obtaining a new drug: discovery, design and development of a drug.
7. The role of regulatory authorities (INFARMED, EMA and FDA) in drug approval.
Teaching Methods
The teaching / learning process is based on students' individual work. Theoretical classes are exposition classes, with exercises being solved, clarification of doubts and discussion of some topics. Laboratory classes is based on planning and execution of laboratory works that give practical examples of theoretical contents.
The assessment will be based on measuring the acquisition and understanding of knowledge and the skills developed in the various components. The evaluation of the theoretical component will take place by final exam (65%). The evaluation of the practical component will be obtained based on participation, practical work and report writing (10%); students with special attendance regimens or those who have not been approved may take a practical laboratory exam. The evaluation is complemented by the presentation of an article, or a work on a drug or other subject (25%).
The assessment will be based on measuring the acquisition and understanding of knowledge and the skills developed in the various components. The evaluation of the theoretical component will take place by final exam (65%). The evaluation of the practical component will be obtained based on participation, practical work and report writing (10%); students with special attendance regimens or those who have not been approved may take a practical laboratory exam. The evaluation is complemented by the presentation of an article, or a work on a drug or other subject (25%).
