2023
Fundaments of Biologic Engineering
Name: Fundaments of Biologic Engineering
Code: QUI13624L
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Biochemistry, Chemistry
Teaching languages: Portuguese
Languages of tutoring support: Portuguese, English
Regime de Frequência: Presencial
Sustainable Development Goals
Learning Goals
Performing mass and energy balances with and without reaction to bioprocesses. Know the difference between laminar and turbulent flow. Knowing what they are Newtonian fluids and non-Newtonian; describe the mechanisms of mixture; correlate the physical properties of fluids with cell growth. Knowing the mechanisms of conduction and convection heat transfer; Knowing the law of Fourier, equipment used to describe heat transfer in bioprocesses. Meet Fick's Law; identify the steps that have increased resistance to oxygen transfer from bubbles to the cells; understand how the transfer of oxygen and kla may limit the density of biomass in fermenters.
Contents
Material and energy balances.
Fluid flow and mixing. Viscosity. Momentum transfer. Non Newtonian fluids. Viscosity measurement. Rheological properties of Fermentation broths. Factors affecting broth viscosity. Mechanism of mixing. Power requirement for mixing. Improving mixing in fermenters. Role of shear in stirred fermenters.
Heat transfer. Mechanism of heat transfer. Conduction. Heat transfer between fluids. Design equations for heat transfer systems. Applications of design equations. Relationship between heat transfer, cell concentration and stirring conditions.
Mass transfer. Molecular diffusion. Theory of diffusion. Analogy between Mass, Heat and Momentum transfer. Role of diffusion in bioprocessing. Film theory. Convective mass transfer. Liquid-liquid mass transfer. Oxygen uptake in cell cultures. Efficiency oxygen transfer in fermenters. Measuring dissolved-oxygen concentrations. Mass transfer correlations. Measurement of kLa.
Fluid flow and mixing. Viscosity. Momentum transfer. Non Newtonian fluids. Viscosity measurement. Rheological properties of Fermentation broths. Factors affecting broth viscosity. Mechanism of mixing. Power requirement for mixing. Improving mixing in fermenters. Role of shear in stirred fermenters.
Heat transfer. Mechanism of heat transfer. Conduction. Heat transfer between fluids. Design equations for heat transfer systems. Applications of design equations. Relationship between heat transfer, cell concentration and stirring conditions.
Mass transfer. Molecular diffusion. Theory of diffusion. Analogy between Mass, Heat and Momentum transfer. Role of diffusion in bioprocessing. Film theory. Convective mass transfer. Liquid-liquid mass transfer. Oxygen uptake in cell cultures. Efficiency oxygen transfer in fermenters. Measuring dissolved-oxygen concentrations. Mass transfer correlations. Measurement of kLa.
Teaching Methods
The lectures will have an exposition of the topics under development.
Theoretical-practical classes will solve problems on the subjects taught. In the laboratory practical will be done a practical work.
The UC has 4 modules: Fluid Mechanics; Mass and Energy Balance; Heat Transfer and Mass Transfer.
At the end of each module a mini-test will be performed.
The Fluid Mechanics module note is 0.85 x mini-test Note + 0,15x Lab Work Report Note. The note of the Mass and Energy Balances module, the Energy Transfer module and the Mass Transfer module will be the note of the respective mini-test (continuous evaluation). During the semester will be held 4 mini-tests (continuous evaluation).
There will be the possibility of final exam.
The final note will be the sum of the modules note / 4 or the exam note.
The student can always take an exam on the laboratory component.
Theoretical-practical classes will solve problems on the subjects taught. In the laboratory practical will be done a practical work.
The UC has 4 modules: Fluid Mechanics; Mass and Energy Balance; Heat Transfer and Mass Transfer.
At the end of each module a mini-test will be performed.
The Fluid Mechanics module note is 0.85 x mini-test Note + 0,15x Lab Work Report Note. The note of the Mass and Energy Balances module, the Energy Transfer module and the Mass Transfer module will be the note of the respective mini-test (continuous evaluation). During the semester will be held 4 mini-tests (continuous evaluation).
There will be the possibility of final exam.
The final note will be the sum of the modules note / 4 or the exam note.
The student can always take an exam on the laboratory component.
