2025
Synthesis of Bioactive Compounds
Name: Synthesis of Bioactive Compounds
Code: QUI13537M
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Chemistry
Teaching languages: Portuguese
Languages of tutoring support: Portuguese
Sustainable Development Goals
Learning Goals
The general objective of this course unit is to provide students with a set of knowledge on the synthesis of bioactive molecules, mainly in an efficient and sustainable way.
The curricular unit will allow the acquisition of the following competences: a) to know fundamental principles of organic synthesis applied to obtain target molecules; b) know techniques used to control the regioselectivity and stereoselectivity of the product; c) to "green" methods for obtaining high value products; d) know issues related to the scale up of API synthesis at industrial scale; e) recognize the importance of results dissemination and protection of intellectual property.
The curricular unit will allow the acquisition of the following competences: a) to know fundamental principles of organic synthesis applied to obtain target molecules; b) know techniques used to control the regioselectivity and stereoselectivity of the product; c) to "green" methods for obtaining high value products; d) know issues related to the scale up of API synthesis at industrial scale; e) recognize the importance of results dissemination and protection of intellectual property.
Contents
Importance of bioactive molecules and fields of action (drugs, biocides, etc). Chemical Synthesis in obtaining bioactive molecules. Chemical Synthesis in the discovery and planning of new bioactive molecules. Target-oriented synthesis, diversity-oriented synthesis and structure-based design. Retrossynthetic analysis. Interconversion of Functional Groups. Transition metal catalyzed cross coupling reactions: examples. Molecular rearrangements. Asymmetric synthesis. Stereoselectivity and Regioselectivity. Sustainable Chemical Synthesis; new synthesis processes with green technologies: biocatalysis, microwave assisted synthesis, etc. Synthesis of APIs on an industrial scale; approach to scale-up. Equipment, purity and control at different stages of synthesis at industrial level. Product separation, purification and drying. Dissemination of results and protection of intellectual property. Patents.
Teaching Methods
Throughout the course different teaching tools are used. In addition to classroom and practical classes, the student is also motivated to solve various exercises at home. The University's e-learning platform is also used to disseminate the material used in the classes and to conduct mini-tests.
The assessment will be based on measuring the acquisition and understanding of knowledge and measuring the development of skills in the various components of the discipline. The evaluation is conducted principally on the basis of a final exam with an option for two tests (representing 75% of the final grade). This assessment is complemented by continuous assessment of students' interest and performance during the semester, mini-tests, participation in seminars, and some laboratory work (representing 25% of the final grade).
The assessment will be based on measuring the acquisition and understanding of knowledge and measuring the development of skills in the various components of the discipline. The evaluation is conducted principally on the basis of a final exam with an option for two tests (representing 75% of the final grade). This assessment is complemented by continuous assessment of students' interest and performance during the semester, mini-tests, participation in seminars, and some laboratory work (representing 25% of the final grade).
Certificações
