2024
Advanced Methods in Organic Synthesis
Name: Advanced Methods in Organic Synthesis
Code: QUI13581D
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Chemistry
Teaching languages: Portuguese
Languages of tutoring support: Portuguese
Sustainable Development Goals
Learning Goals
The students will be expected to be able to understand new modern methods for obtaining important target molecules that include, pharmaceuticals, health care products, agrochemicals etc. A strong emphasis will be placed on the application of catalytic methods and sustainable methods in general. The student will become very proficient in designing sustainable and economic routes to key target products. This knowledge and practise will allow the students to plan and devise efficient reaction pathways to any molecule.
The students will become more experienced in problem solving; principally in the context of chemical reactivity.
The students will become more experienced in problem solving; principally in the context of chemical reactivity.
Contents
Target-oriented synthesis, diversity-oriented synthesis and sustainable synthesis.
Modern catalytic methods, chemocatalytic and biocatalytic methods, organocatalysis and metal-based coupling procedures.
Advanced retrosynthetic analysis.
Heterocycle synthesis.
Modern enabling technologies; alternative solvents, continuous flow processes, microwave assisted synthesis.
Radical based synthesis (photocatalysis).
Synthesis of APIs on an industrial scale; approach to scale-up. Equipment, purity and control at different stages of synthesis at industrial level. Product separation and purification.
Modern catalytic methods, chemocatalytic and biocatalytic methods, organocatalysis and metal-based coupling procedures.
Advanced retrosynthetic analysis.
Heterocycle synthesis.
Modern enabling technologies; alternative solvents, continuous flow processes, microwave assisted synthesis.
Radical based synthesis (photocatalysis).
Synthesis of APIs on an industrial scale; approach to scale-up. Equipment, purity and control at different stages of synthesis at industrial level. Product separation and purification.
Teaching Methods
Throughout the semester different teaching methods are used. In addition to classroom teaching, the student is also motivated to solve various exercises at home. The University's e-learning platform is also used to disseminate the lecture material and to conduct mini-tests.
The assessment will be based on measuring the acquisition and understanding of knowledge and measuring the development of skills in the various components of the discipline. The evaluation of the theoretical components will take place through a final exam through a written test (representing 75% of the final grade). This assessment is complemented by the continuous assessment of the students' performance during the semester, by mini-tests (online) and by their participation in seminars (representing 25% of the final grade).
The assessment will be based on measuring the acquisition and understanding of knowledge and measuring the development of skills in the various components of the discipline. The evaluation of the theoretical components will take place through a final exam through a written test (representing 75% of the final grade). This assessment is complemented by the continuous assessment of the students' performance during the semester, by mini-tests (online) and by their participation in seminars (representing 25% of the final grade).
Certificações
