2024
Toxicology and Toxicological Analysis
Name: Toxicology and Toxicological Analysis
Code: CMS13777I
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Biochemistry, Biological Sciences
Teaching languages: Portuguese
Languages of tutoring support: Portuguese
Presentation
This UC aims to provide students with fundamental knowledge about nature, biotransformation, mechanisms of action and main effects caused by the most common chemicals and their residues and radiation in biological systems at the biochemical level.
Sustainable Development Goals
Learning Goals
Provide:
- Knowledge of fundamental concepts about nature, biotransformation, mechanisms of action and main effects caused by the most common chemicals, their residues and radiation in biological systems at the biochemical level; the understanding of integrating concepts, processes and methods to access knowledge and solve practical problems related to the safety and toxicity of the most common chemicals and radiation; the development of the ability to select and apply knowledge in the formulation of hypotheses, experimental planning, and obtaining and treating results, with a view to solving qualitative or quantitative problems of a family nature in the scope of the subjects dealt with.
- Skills to collect, interpret and criticize relevant scientific information, in oral and written form, organized in a coherent and logical way on subjects within the scope of the discipline.
- Knowledge of fundamental concepts about nature, biotransformation, mechanisms of action and main effects caused by the most common chemicals, their residues and radiation in biological systems at the biochemical level; the understanding of integrating concepts, processes and methods to access knowledge and solve practical problems related to the safety and toxicity of the most common chemicals and radiation; the development of the ability to select and apply knowledge in the formulation of hypotheses, experimental planning, and obtaining and treating results, with a view to solving qualitative or quantitative problems of a family nature in the scope of the subjects dealt with.
- Skills to collect, interpret and criticize relevant scientific information, in oral and written form, organized in a coherent and logical way on subjects within the scope of the discipline.
Contents
Scope and history of Toxicology
Dose-response relationship and factors that affect it
Interaction between xenobiotic
Tolerance to xenobiotics
Absorption, distribution, excretion, biotransformation, results and consequences, and disposal of toxics.
Cellular and biochemical mechanisms of toxicity: organ and tissue damage; mechanisms of cytotoxicity, immunotoxicity, teratogenesis, genotoxicity, chemical carcinogenesis and multi-organ toxicity.
Risks to the health of individuals and the environment due to toxics, their residues and radiation.
Toxic agents: solvents and vapors; metals; pesticides; drugs of abuse; everyday products.
Clinical toxicity.
Forensic toxicity.
Safety in production, packaging, transport, storage, dispensing and use of toxic substances.
Dose-response relationship and factors that affect it
Interaction between xenobiotic
Tolerance to xenobiotics
Absorption, distribution, excretion, biotransformation, results and consequences, and disposal of toxics.
Cellular and biochemical mechanisms of toxicity: organ and tissue damage; mechanisms of cytotoxicity, immunotoxicity, teratogenesis, genotoxicity, chemical carcinogenesis and multi-organ toxicity.
Risks to the health of individuals and the environment due to toxics, their residues and radiation.
Toxic agents: solvents and vapors; metals; pesticides; drugs of abuse; everyday products.
Clinical toxicity.
Forensic toxicity.
Safety in production, packaging, transport, storage, dispensing and use of toxic substances.
Teaching Methods
Collective contact sessions for the transmission of fundamental knowledge using active methodologies that appeal to student / student interaction, such as practical activities, debates, group / peer research work, problem solving / exploring CTS & A situations, which allows learning cooperative, a very effective method of solving problems and promoting learning.
The evaluation will be carried out in two components: one pratical (40%), in a group, by presenting and discussing the results obtained from carrying out practical work; another, by written evaluation (60%), which, by option, can be for the accomplishment of 2 written tests in the middle and at the end of the semester or just 1 final written exam.
The evaluation will be carried out in two components: one pratical (40%), in a group, by presenting and discussing the results obtained from carrying out practical work; another, by written evaluation (60%), which, by option, can be for the accomplishment of 2 written tests in the middle and at the end of the semester or just 1 final written exam.
Certificações
