2024
Hematology
Name: Hematology
Code: CMS13771I
6 ECTS
Duration: 15 weeks/156 hours
Scientific Area:
Biochemistry, Biological Sciences
Teaching languages: Portuguese
Languages of tutoring support: Portuguese
Presentation
system, as well as, laboratorial techniques used in diagnosis, prognosis, monitoring and assistance with therapy in Hematology recognizing classic and innovative therapies in the hematological context.
Sustainable Development Goals
Learning Goals
The unit's overall objective is to acquire, at an introductory level, knowledge about the morphology, constituents and function of the hematopoietic system in normal physiological states and in dysfunction scenarios, as well as the main laboratory techniques used in diagnosis, prognosis, monitoring and assistance with therapy in Hematology. Additionally, it is intended that the students recognize classic and innovative therapies in the hematological context.
The skills to be developed are:
- Knowledge of hematopoiesis and figured elements of the blood (structure, morphology and functions).
- Understanding of the etiology and cellular, biochemical and molecular mechanisms underlying hematopoietic diseases and methodologies to study these pathologies.
- Interpret laboratory tests results for the diagnosis, prognosis and therapeutic monitoring of hematopoietic pathologies.
- Recognize the relevance of research in hematology in the development of emerging therapeutic strategies.
The skills to be developed are:
- Knowledge of hematopoiesis and figured elements of the blood (structure, morphology and functions).
- Understanding of the etiology and cellular, biochemical and molecular mechanisms underlying hematopoietic diseases and methodologies to study these pathologies.
- Interpret laboratory tests results for the diagnosis, prognosis and therapeutic monitoring of hematopoietic pathologies.
- Recognize the relevance of research in hematology in the development of emerging therapeutic strategies.
Contents
Principles of hematology: Overview. Cell lines; hemopoiesis; bone marrow; spleen.
Erythrocytes and hemoglobin: structure and function; erythropoiesis; Iron and hem metabolism; Metabolism; full blood and reticulocyte count; peripheral blood film.
Erythrocyte disorders. Anemia: hematinic; chronic; hemolytic; Hemoglobinopathies; Investigation; Anemia due to blood loss; Marrow defects; Polycythemia.
Leucocytes. Structure and function; differentiation; differential count; reactive proliferation; leucopenia.
Hematological malignancies: overview; classification and pathogenesis; research.
Hemostasis: platelets and coagulation; platelet and clotting factor disorders; coagulation cascade; clotting tests; thrombosis.
Lab Hematology: Reference intervals and normal levels as a basis for diagnostics and monitorization; therapeutic applications.
Pharmacotherapy of hematological disorders: classical small molecule therapies; Molecular Hematology and novel therapeutics (SMIs; mAbs, iRNA, microRNA).
Erythrocytes and hemoglobin: structure and function; erythropoiesis; Iron and hem metabolism; Metabolism; full blood and reticulocyte count; peripheral blood film.
Erythrocyte disorders. Anemia: hematinic; chronic; hemolytic; Hemoglobinopathies; Investigation; Anemia due to blood loss; Marrow defects; Polycythemia.
Leucocytes. Structure and function; differentiation; differential count; reactive proliferation; leucopenia.
Hematological malignancies: overview; classification and pathogenesis; research.
Hemostasis: platelets and coagulation; platelet and clotting factor disorders; coagulation cascade; clotting tests; thrombosis.
Lab Hematology: Reference intervals and normal levels as a basis for diagnostics and monitorization; therapeutic applications.
Pharmacotherapy of hematological disorders: classical small molecule therapies; Molecular Hematology and novel therapeutics (SMIs; mAbs, iRNA, microRNA).
Teaching Methods
The curricular unit will work using three types of class:
Theoretical. Expositive with audiovisuals support (PPT, videos, computer simulations), but students participation is encouraged by asking questions, posing problems and clinical cases, encouraging generalized discussions, thus helping students co-relating the different items of the program with issues immanent to the active practice of hematology.
Theoretical-practical. Presentation and discussion of scientific articles and clinical cases, for application and clarification of theoretical concepts, while simultaneously addressing the state of the art.
Laboratory. Execution of routine methodologies in a hematology laboratory, interpretation and discussion of the results, allowing a full application of the theoretical knowledge, and sedimented through the submission of reports.
The evaluation will consist of three components:
Two tests or final written exam (60%).
Laboratory reports (15%).
Assessment of laboratory work (25%).
Theoretical. Expositive with audiovisuals support (PPT, videos, computer simulations), but students participation is encouraged by asking questions, posing problems and clinical cases, encouraging generalized discussions, thus helping students co-relating the different items of the program with issues immanent to the active practice of hematology.
Theoretical-practical. Presentation and discussion of scientific articles and clinical cases, for application and clarification of theoretical concepts, while simultaneously addressing the state of the art.
Laboratory. Execution of routine methodologies in a hematology laboratory, interpretation and discussion of the results, allowing a full application of the theoretical knowledge, and sedimented through the submission of reports.
The evaluation will consist of three components:
Two tests or final written exam (60%).
Laboratory reports (15%).
Assessment of laboratory work (25%).
Certificações
