Pharmacology and Toxicology

Code: CMS11476L

6 ECTS

Duration: 15 weeks/156 hours

Scientific Area: Biochemistry

Teaching languages: Portuguese

Languages of tutoring support: Portuguese, English

Regime de Frequência: Presencial

Sustainable Development Goals

4. Educação de qualidade - Assegurar a educação inclusiva, e equitativa e de qualidade, e promover oportunidades de aprendizagem ao longo da vida para todos.

Learning Goals

Objectives
Distinguish between action and effect
Understanding the mechanisms of absorption, distribution, metabolism and distribution of xenobíótiocos
Knowing the different modes of action of several drugs
Knowing the factors affecting toxicity
Knowing the different toxic responses to xenobiotics

Competences
Understand the importance of structure and form of the xenobiotic esterioquímica to determine the mechanisms of absorption, distribution, metabolism and distribution
Infer the change of the pharmacological effect of toxic effect
Select and apply knowledge in the formulation of hypotheses, experimental design, and obtaining and processing of results, with a view to problem solving qualitative or quantitative in nature within the family matters dealt.

Xenobiotics with pharmacological and toxicological interest
Pharmacological and toxicological kinetics
Absorption, distribution, metabolism and excretion
Pharmacological and toxicological dynamics
Local action and action at a distance
Shape and structural stereochemistry of xenobiotics
Pharmacology
Different classes of drugs
Drugs that act at neuroefectors junctions and peripheral synapses
Drugs with actions on the central nervous system
Autacoids
Drugs affecting renal and cardiovascular functions
Drugs affecting gastrointestinal function
Chemotherapy anti-microbial and anti-parasitic
Chemotherapy of neoplastic diseases
Immunomodulation therapy
Drugs acting on blood and blood forming organs
Hormones and their antagonists
Toxicology
Factors affecting toxic response, metabolism and disposition
Toxic responses of xenobiotics
Biochemical mechanisms of toxicity

Teaching Methods

Collective Sessions Contact transmission of fundamental knowledge which will be used methodologies active calling for the interaction student / student, such as practical activities, discussions, research work in groups / pairs, problem solving / exploration of situations STS & E, which allows learning cooperative, very effective method to solve problems and promote learning.
Laboratory classes allow the consolidation of theoretical concepts through the performance of experimental activities, the analysis of results, and their dissemination, either through written reports or oral presentations.

Assessment

The assessment of the course unit is structured to ensure that students develop balanced skills in both theoretical and laboratory practice components. To pass the course, a minimum grade of 10 out of 20 is required in each of the components.

The laboratory component (PL) accounts for 25% of the final grade, valuing performance and practical skills acquired during laboratory sessions.

The theoretical assessment (T) is carried out in two possible modalities:

a) Continuous assessment:
This includes three main elements:

Participation in classes and TBL activities (10%)

Presentation of a monograph (15%), encouraging active participation, teamwork, and scientific communication skills

Two written tests (T1 and T2), each weighted at 25%, representing a total of 50% of the final grade

Final grade = (PL × 25%) + (T1 × 25%) + (T2 × 25%) + (TBL/activities × 10%) + (Monograph × 15%)

b) Final assessment:
Completion of a written exam (E) weighted at 75%

Final grade = (PL × 25%) + (E × 75%)

The final grade results from the weighted contribution of the different components, and a minimum passing grade in each is required in order to pass the course unit.